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KMID : 1123920060200040997
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Korean Journal of Oriental Physiology and Pathology
2006 Volume.20 No. 4 p.997 ~ p.1008
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Effects of ChongMyung-Tang and ChongMyung-Tang added Moutan Cortex Hot water extract & Ultra-fine Powder on Microglia and Memory Deficit Model
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Lim Jung-Hwa
Jung In-Chul
Lee Sang-Ryong
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Abstract
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This experiment was designed to investigate the effect of the CMT and PCMT hot water extract & ultra-fine powder on microglia and memory deficit model. The effects of the CMT and PCMT hot water extract on expression of , NOS-II, COX-2, IL-10, mRNA and production of , NO, ROS in BV2 microglial cell line treated by lipopolysacchaide(LPS) , serum glucose, uric acid, AChE activity of the memory deficit mice induced by scopolamine , behavior of the memory deficit mice induced by scopolamine and were investigated, respectively. The CMT and PCMT hot water extract suppressed the expression of , NOS-11, COX-2 mRNA, production of , NO, ROS and increased the expression of IL-10, mRNA in BV2 microglial cell line treated by LPS. The PCMT hot water extract & ultra-fine powder increased glucose, decreased uric acid and AChE significantly in the serum of the memory deficit mice induced by scopolamine. The CMT and PCMT hot water extract & ultra-fine powder groups showed significantly inhibitory effect on the scopolamine-induced impairment of memory in the experiment of Morris water maze. According to the above result, it is suggested that the CMT and PCMT hot water extract & ultra-fine powder might be usefully applied for prevention and treatment of dementia.
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KEYWORD
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Microglia, Dementia, ChongMyung-Tang(CMT), ChongMyung-Tang added Moutan Cortex (PCMT), Hot water extract & Ultra-fine powder
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